KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
8.48
Human Site:
S352
Identified Species:
18.67
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
S352
K
M
E
I
K
E
S
S
S
F
D
F
R
T
S
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S352
K
M
E
I
K
E
S
S
S
F
D
F
R
T
S
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
S352
K
M
E
N
T
E
S
S
S
F
D
F
R
T
S
Dog
Lupus familis
XP_540240
893
101055
A437
Q
R
L
R
V
K
S
A
E
A
S
S
F
E
F
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
E348
Q
H
S
K
Q
G
A
E
A
E
S
T
G
G
S
Rat
Rattus norvegicus
NP_001099930
804
89584
E348
Q
Q
S
K
Q
G
A
E
A
E
S
T
E
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
G342
T
W
K
L
L
K
D
G
I
I
P
V
N
F
N
Chicken
Gallus gallus
XP_001235234
775
85980
V322
P
K
P
L
L
T
P
V
E
D
I
Y
S
L
S
Frog
Xenopus laevis
NP_001084841
660
74123
D207
H
D
V
P
S
S
F
D
S
I
L
D
M
I
G
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
M117
T
V
L
D
F
W
R
M
I
W
E
Y
K
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
P371
E
L
P
M
P
K
L
P
S
G
P
P
K
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
100
86.6
6.6
N.A.
6.6
6.6
N.A.
0
6.6
6.6
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
86.6
26.6
N.A.
33.3
33.3
N.A.
26.6
20
6.6
40
N.A.
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
19
10
19
10
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
10
0
0
10
10
0
10
28
10
0
0
0
% D
% Glu:
10
0
28
0
0
28
0
19
19
19
10
0
10
10
0
% E
% Phe:
0
0
0
0
10
0
10
0
0
28
0
28
10
10
10
% F
% Gly:
0
0
0
0
0
19
0
10
0
10
0
0
10
10
10
% G
% His:
10
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
19
0
0
0
0
19
19
10
0
0
10
0
% I
% Lys:
28
10
10
19
19
28
0
0
0
0
0
0
19
0
0
% K
% Leu:
0
10
19
19
19
0
10
0
0
0
10
0
0
10
0
% L
% Met:
0
28
0
10
0
0
0
10
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
10
% N
% Pro:
10
0
19
10
10
0
10
10
0
0
19
10
0
0
0
% P
% Gln:
28
10
0
0
19
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
10
0
0
10
0
0
0
0
0
28
0
0
% R
% Ser:
0
0
19
0
10
10
37
28
46
0
28
10
10
10
64
% S
% Thr:
19
0
0
0
10
10
0
0
0
0
0
19
0
28
0
% T
% Val:
0
10
10
0
10
0
0
10
0
0
0
10
0
19
0
% V
% Trp:
0
10
0
0
0
10
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
19
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _